The direct binding of bioactive peptide Andersonin-W1 to TLR4 expedites the healing of diabetic skin wounds

CONCLUSIONS: AW1 modulates inflammation and the wound healing process by the TLR4/NF-κB molecular axis, thus facilitating reepithelialization, granulation regeneration, and angiogenesis. These findings not only provided a promising multifunctional prohealing drug candidate for chronic nonhealing skin wounds but also highlighted the unique roles of "small" peptides in the elucidation of "big" human disease mechanisms.PMID:38317065 | PMC:PMC10845795 | DOI:10.1186/s11658-024-00542-4

Source: Cellular and Molecular Biology Letters - February 5, 2024 Category: Biochemistry Authors: Chao Li Yuxin Xiong Zhe Fu Yuxin Ji Jiayi Yan Yan Kong Ying Peng Zeqiong Ru Yubing Huang Yilin Li Ying Yang Li He Jing Tang Ying Wang Xinwang Yang Source Type: research