Enhanced glutathione levels confer resistance to apoptotic and ferroptotic programmed cell death in NEIL DNA glycosylase deficient HAP1 cells

This study reveals an unforeseen role of NEIL glycosylases in regulation of resistance to oxidative stress, suggesting that modulation of NEIL glycosylase activities is a potential approach to improve the efficacy of e.g. anti-inflammatory therapies.PMID:38301978 | DOI:10.1016/j.freeradbiomed.2024.01.037

Source: Free Radical Biology and Medicine - February 1, 2024 Category: Biology Authors: Christine Gran Neurauter Marco Pannone Mirta Mittelstedt Leal de Sousa Wei Wang Anna Ku śnierczyk Luisa Luna P ål Sætrom Katja Scheffler Magnar Bj ørås Source Type: research