Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability

This study provides a new pharmacophore for WRN inhibitors, emphasizing their therapeutic potential for MSI cancers.PMID:38295487 | DOI:10.1016/j.bmc.2024.117588

Source: Bioorganic and Medicinal Chemistry - January 31, 2024 Category: Chemistry Authors: Hwasun Yang Miso Kang Seonyeong Jang Soo Yeon Baek Jiwon Kim Gyeong Un Kim Dongwoo Kim Junsu Ha Jong Seung Kim Cheulhee Jung Nam-Jung Kim Sung-Yup Cho Woong-Hee Shin Juyong Lee Junsu Ko Ansoo Lee Gyochang Keum Sanghee Lee Taek Kang Source Type: research