Insights into the role of JAK2-I724T variant in myeloproliferative neoplasms from a unique cohort of New Zealand patients

CONCLUSION: Several non-canonical JAK2 variants with high REVEL scores have been reported in MPN, highlighting the need to further understand their relationship with disease. The JAK2-I724T variant does not drive MPN, but additional investigations are required to exclude any potential modulatory effect on the MPN phenotype.PMID:38197452 | DOI:10.1080/16078454.2023.2297597

Source: Hematology - January 10, 2024 Category: Hematology Authors: Christopher Puli'uvea Tracey Immanuel Taryn N Green Peter Tsai Peter R Shepherd Maggie L Kalev-Zylinska Source Type: research