Altered peripheral blood leukocyte subpopulations, function, and gene expression in children with Down syndrome: implications for respiratory tract infection
CONCLUSIONS: Increased susceptibility to severe and chronic infection in children with DS may result from inappropriate numbers and subtypes of immune cells that are phenotypically and functionally altered due to trisomy 21 associated interferonopathy.PMID:38325643 | DOI:10.1016/j.ejmg.2024.104922
Source: European Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Kelley L Colvin Kristine Wolter-Warmerdam Francis Hickey Michael E Yeager Source Type: research