PACE: randomized, controlled, multicentre, multinational, phase III study of PLX-PAD for critical limb ischaemia in patients unsuitable for revascularization: randomized clinical trial

CONCLUSION: Although there was no evidence that PLX-PAD reduced amputation-free survival in the entire study population, benefit was observed in patients without diabetes mellitus or whose diabetes was well controlled; this requires confirmation in further studies. Trial registration: NCT03006770 (http://www.clinicaltrials.gov); 2015-005532-18 (EudraCT Clinical Trials register - Search for 2015-005532-18).PMID:38294084 | PMC:PMC10828925 | DOI:10.1093/bjs/znad437

Source: The British Journal of Surgery - January 31, 2024 Category: Surgery Authors: Lars Norgren Norbert Weiss Sigrid Nikol John C Lantis Manesh R Patel Robert J Hinchliffe Holger Reinecke Hans Dieter Volk Petra Reinke Gian Paolo Fadini Racheli Ofir Daniel Rothenstein Nitsan Halevy Mitko Karagjozov John H Rundback Source Type: research