New strategies for confirmatory testing of secondary hypotheses on combined data from multiple trials

CONCLUSIONS: Inference on combined data across trials is a useful approach for generating pivotal evidence of efficacy for important but sample size-intense secondary endpoints. It requires careful preparation and regulatory discussion.PMID:38311901 | DOI:10.1177/17407745231214382

Source: Clinical Trials - February 5, 2024 Category: Research Authors: Marc Vandemeulebroecke Dieter A H äring Eva Hua Xiaoling Wei Dong Xi Source Type: research