Postexercise reflex facilitation in Lambert-Eaton myasthenic syndrome

Pract Neurol. 2024 Jan 30:pn-2023-004032. doi: 10.1136/pn-2023-004032. Online ahead of print.ABSTRACTA 62-year-old woman had 6 months of proximal weakness, fatigue and occasional diplopia, symptoms normally suggesting myasthenia gravis or inflammatory myopathy. Postexercise reflex facilitation is a bedside clinical sign that points to a diagnosis of the rarer alternative, Lambert-Eaton myasthenic syndrome (LEMS). We confirmed this diagnosis using electrodiagnostic short exercise testing and serum assay for voltage-gated calcium channel antibodies. Further investigation identified a small cell neuroendocrine carcinoma of the gallbladder, not previously associated with LEMS. Postexercise reflex facilitation is an important bedside clinical finding that helps clinicians to distinguish LEMS from its mimics.PMID:38290844 | DOI:10.1136/pn-2023-004032

Source: Practical Neurology - January 30, 2024 Category: Neurology Authors: Mervyn Poh Yeo Chong Ming Patricia Cheong Yanni Gee Jin Ng Yong Howe Ho Kalpana Prasad Umapathi Thirugnanam Source Type: research