< em > In  vitro < /em > characterization of rare anti- α < sub > IIb < /sub > β < sub > 3 < /sub > isoantibodies produced by patients with Glanzmann thrombasthenia that severely block fibrinogen binding and generate procoagulant platelets via complement activation

CONCLUSION: Our data suggest that complement activation induced by rare blocking anti-αIIbβ3 isoantibodies may lead to the formation of a MAC with subsequent pore formation, resulting in calcium influx and procoagulant platelet phenotype.PMID:38268518 | PMC:PMC10805943 | DOI:10.1016/j.rpth.2023.102253

Source: Thrombosis and Haemostasis - January 25, 2024 Category: Hematology Authors: Christine S M Lee Yoann Huguenin Xavier Pillois Mikeldi Moulieras Ella Marcy Shane Whittaker Vivien M Y Chen Mathieu Fiore Source Type: research