Comparing Methods for Induction of Insulin Resistance in Mouse 3T3-L1 Cells

CONCLUSION: In summary, different in vitro models using inflammatory, oxidative stress, and high insulin conditions under hypoxic conditions can capture various aspects of in vivo adipose tissue insulin resistance (IR). Among these models, acute TNFα treatment may offer the most robust approach for inducing IR in 3T3-L1 cells.PMID:38204253 | DOI:10.2174/0115733998263359231211044539
Source: Current Diabetes Reviews - Category: Endocrinology Authors: Source Type: research