Reno-protective effect of protocatechuic acid is independent of sex-related differences in murine model of UUO-induced kidney injury

CONCLUSION: Our findings suggest a differential gender response to UUO-induced kidney injury with males being more sensitive to UUO-induced kidney inflammation, fibrosis, and apoptosis than age-matched females. Importantly, PCA treatment reduced UUO-induced kidney injury in a sex-independent manner which might be attributed to its anti-oxidant, anti-inflammatory, anti-fibrotic, and anti-apoptotic properties.PMID:38214881 | DOI:10.1007/s43440-023-00565-2

Source: Pharmacological Reports - January 12, 2024 Category: Drugs & Pharmacology Authors: Karim M Saad Évila Lopes Salles Sahar Emami Naeini Babak Baban Marwa E Abdelmageed Rania R Abdelaziz Ghada M Suddek Ahmed A Elmarakby Source Type: research