tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis

In conclusion, tRF3-IleAAT inhibits ferroptosis by targeting ZNF281, resulting in the mitigation of ECM synthesis in DKD models, suggesting that tRF3-IleAAT may be an attractive therapeutic target for DKD.PMID:38286833 | DOI:10.1038/s41401-024-01228-5

Source: Acta Pharmacologica Sinica - January 29, 2024 Category: Drugs & Pharmacology Authors: Yun-Yang Qiao Jia-Ling Ji Wei-Ling Hou Gao-Ting Qu Shan-Wen Li Xing-Yue Li Ran Jin Yin-Fang Li Hui-Min Shi Ai-Qing Zhang Source Type: research