Association of Lipoprotein (a) with Peri-coronary Inflammation in Persons with and without HIV Infection

Persons with human immunodeficiency virus (HIV) (PWH) have an approximately 2-fold increased risk of developing cardiovascular disease (CVD) than those without HIV (PWoH)1-2. This increased CVD risk may be due to chronic systemic inflammation and immune activation in PWH3. Lipoprotein (a) (Lp(a)), a subclass of low-density lipoprotein (LDL), is an independent atherosclerotic risk factor in PWoH4-5. While elevated Lp(a) levels may occur in PWH6, few studies have investigated the association of Lp(a) and subclinical atherosclerosis7-8, and no studies have evaluated its association with peri-coronary inflammation.

Source: Journal of Clinical Lipidology - February 14, 2024 Category: Lipidology Authors: Erin Zisman, Mian Hossain, Nicholas T. Funderburg, Robert Christenson, Jean Jeudy, Shana Burrowes, Allison G. Hays, Nivya George, Michael L. Freeman, Heather Rebuck, Sarah E. Mitchell, Michael Miller, Shashwatee Bagchi Tags: Original Research Source Type: research