Implementation and evaluation of a dynamic contrast-enhanced MR perfusion protocol for glioblastoma using a 0.35  T MRI-Linac system

The Response Assessment in Neuro-Oncology (RANO) is often applied to measure glioblastoma response on MRI. These criteria primarily compare volumetric changes on post-contrast three-dimensional T1 weighted (3D-T1w) and T2-weighted fluid-attenuated inversion recovery (T2-FLAIR) images[1]. MRIs are usually obtained one month before radiotherapy (RT) start and one month after treatment completion. This relatively long interval, approximately 3  months, does not permit early adaptation of RT for poorly responding tumors and reflects the uncertainty often seen in early post-RT MRI[2,3].
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Source Type: research