Sfrp1 inhibits lung fibroblast invasion during transition to injury-induced myofibroblasts

Conclusions
Our study reveals the convergence of spatially and transcriptionally distinct fibroblast lineages into transcriptionally uniform myofibroblasts and identifies SFRP1 as a modulator of TGFβ1-driven fibroblast phenotypes in fibrogenesis. These findings are relevant in the context of therapeutic interventions that aim at limiting or reversing fibroblast foci formation.

Source: European Respiratory Journal - February 8, 2024 Category: Respiratory Medicine Authors: Mayr, C. H., Sengupta, A., Asgharpour, S., Ansari, M., Pestoni, J. C., Ogar, P., Angelidis, I., Liontos, A., Rodriguez-Castillo, J. A., Lang, N. J., Strunz, M., Porras-Gonzalez, D., Gerckens, M., De Sadeleer, L. J., Oehrle, B., Viteri-Alvarez, V., Fernand Tags: Mechanisms of lung disease Original Articles: Basic mechanisms of disease Source Type: research