A Pawn's Sacrifice: Go for the Win

Although neoadjuvant chemotherapy with immunotherapy (IO) before surgery is a standard,12 there is no standard at this time to recommend systemic therapy alone for local disease. Thus, local consolidation with radiation therapy (RT) should be offered with no further role for chemotherapy. Ideally, RT would start after an adequate recovery period from what seems to be grade 2 pneumonitis. In the PACIFIC-6 trial,3 primarily older patients (>65) received sequential chemotherapy then RT (followed by adjuvant durvalumab), which portended a favorable toxicity profile and favorable efficacy.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research