Plasma Proteome Analyses Identify Predictors of Graft Rejection Prior to Stem Cell Infusion and Support Interferon-Mediated Ferroptosis As a Novel Mechanism of Graft Rejection

No established biomarkers or effective interventions exist for graft rejection. We previously reported that CXCL9, a downstream marker of interferon, differentiates graft rejection from other complications but is only useful at the time of rejection. We hypothesized that biological differences in the host proteome exist prior to HSCT and that interferon-mediated pathways drive host elimination of donor cells during graft rejection.

Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Dr. Anthony Sabulski, Lucille Langenberg, Nathan Luebbering, Towia A Libermann, Simon T Dillon, Jane Koo, Kasiani C Myers, Sonata Jodele, Stella M. Davies Tags: 6 Source Type: research