Ceramides Are Elevated in Transplant-Associated Thrombotic Microangiopathy in Hematopoietic Stem Cell Transplant Recipients and Are a Druggable Target for Prophylaxis.

Ceramides (Cer) are sphingolipids critical to maintaining endothelial barrier homeostasis and integrity. Ceramides cause oxidative stress in human endothelial cells, thereby reducing levels of bioactive nitric oxide (NO). NO inhibits platelet aggregation, prevents adhesion of platelets to the endothelial surface and induces disaggregation of aggregating platelets. We hypothesized that disruption of ceramides contributes to the etiology of TA-TMA and that ceramides represent a target for prophylaxis.

Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Jane Koo, Lucille Langenberg, Nathan Luebbering, Lauren Strecker, Sheyar Abdullah, Elizabeth Carusone, Marisa Deavy, Colin Hoerth, Gillian Miller, Deena Turner, Kelly E. Lake, Kenneth Setchell, Wujuan Zhang, Xueheng Zhao, Assem G. Ziady, Kasiani C Myers, Tags: 21 Source Type: research