Unrelated and Haploidentical Peripheral Stem Cell Transplant with Tcr αβ/CD19 Depletion for the Treatment of Pediatric Patients with Inborn Errors of Immunity

Hematopoietic stem cell transplant (SCT) is curative therapy for many inborn errors of immunity (IEIs). Yet, only a minority of recipients have a suitable HLA matched related donor. Ex vivo TCR αβ/CD19 depletion allows the use of unrelated or partially matched related donors while reducing the risk of GVHD by removing alloreactive αβ T-cells but retaining γδ T-cells. Here, we present a single institution experience with TCRαβ/CD19 depleted PSCT for treatment of IEIs.

https://www.astctjournal.org/article/S2666-6367(23)01843-2/fulltext?rss=yes

Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Susan E. McClory, Caitlin W. Elgarten, Kaitlyn N Quijano, Anne Wohlschlaeger, Mrs. Patricia Hankins, Lei Wang, Yongping Wang, Stephan Kadauke, Dimitri Monos, Timothy S. Olson, Stephan A. Grupp, Elisa Ochfeld, Jennifer R. Heimall, Nancy J. Bunin Tags: 78 Source Type: research