Dopamine transmission in the tail striatum: Regional variation and contribution of dopamine clearance mechanisms

We recorded evoked dopamine release in the four tail striatum divisions (dorsal and trilaminar medial, intermediate and lateral) and the dorsolateral striatum, using fast-scan cyclic voltammetry in rat brain slices. Clearance mechanisms were investigated using dopamine transporter knockout (DAT-KO) rats, pharmacological transporter inhibitors and dextran. Dopamine release in all tail divisions was smaller amplitude than in the dorsolateral striatum and, importantly, regional variation was observed. The intermediate division exhibited uniquely low-peak dopamine clearance velocity and high sensitivity to DAT removal. Our findings confirm that not only is the tail striatum a distinct dopamine domain but each tail division. AbstractThe striatum can be divided into four anatomically and functionally distinct domains: the dorsolateral, dorsomedial, ventral and the more recently identified caudolateral (tail) striatum. Dopamine transmission in these striatal domains underlies many important behaviours, yet little is known about this phenomenon in the tail striatum. Furthermore, the tail is divided anatomically into four divisions (dorsal, medial, intermediate and lateral) based on the profile of D1 and D2 dopamine receptor-expressing medium spiny neurons, something that is not seen elsewhere in the striatum. Considering this organisation, how dopamine transmission occurs in the tail striatum is of great interest. We recorded evoked dopamine release in the four tail divisions, with c...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research