Quality assessment of the MRI-radiomics studies for MGMT promoter methylation prediction in glioma: a systematic review and meta-analysis

ConclusionsStudy RQS and adherence to TRIPOD guidelines was generally low. Radiomic prediction of MGMT methylation status showed great heterogeneity of results and lower performances in grade IV gliomas, which hinders its current implementation in clinical practice.Clinical relevance statementMGMT promoter methylation status appears to be variably correlated with MRI radiomic features; radiomic models are not sufficiently robust to be integrated into clinical practice to accurately predict MGMT promoter methylation status in patients with glioma before surgery.Key Points•Adherence to the indications of TRIPOD guidelines was generally low, as was RQS total score.•MGMT promoter methylation status prediction with MRI radiomic features provided heterogeneous diagnostic accuracy results across studies.•Studies that included grade IV glioma only and performed external validation had significantly lower diagnostic accuracy than others.
Source: European Radiology - Category: Radiology Source Type: research