Why is Aspirin, everyone ’ s nemesis ?

Here is a current review on a topic, which needs some soulful Introspection For a kid, A stands for apple in kindergarten, while in the school of cardiac sciences, A would sound as Aspirin. Such is the importance of this drug, known for its obedient, predictable efficiency in the entire spectrum of CAD right from primary prevention of CAD to emergent primary angioplasty in Cath lab. Most of us will also agree, It is a work horse drug for not only for the cardiologists , but been an anchor drug in as many critical medical therapeutics, wherever platelets are to be passivated. We are well aware of molecular basis of this drugs action . Aspirin impacts most points in the core axis of platelet adhesion , activation and aggregation either directly or indirectly .(Though its just a COX 1 blocker) Its efficiency is backed by countless papers with authenticated evidence. Final message “Now, we, realize Aspirin is being targeted and facing potential elimination “ Why is this happening ? Aspirin acts just blocks thromboxane mediated platelet activation , it doesn’t block Adenosine triggered activation so it is useless is the argument. Some how, our thought faculty is intruded , and unable to realize, the same question can be played in reverse . P2-Y12 blockers in whatever form & fashion ,helplessly watch thromboxane A2 to activate platelets, isn’t ? Please understand, many case of Clopidogrel and Ticagrelor resistance is attri...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: Uncategorized acc aha guidelines aspirin bias-against-aspirin dapt esc guidelines mapt Source Type: blogs