EV-mediated intercellular communication in AML: Transport of genetic materials in the bone marrow microenvironment

Acute myeloid leukemia (AML) is the most prevalent acute leukemia in adults. It occurs due to the proliferation of non-functional primitive myeloid cells in the bone marrow (BM), which further spreads to other parts of the body, such as the blood, liver, spleen, and central nervous system [1]. Inadequate understanding of the pathophysiology of AML, as well as the lack of specific diagnostic and therapeutic monitoring tools, limit the therapeutic effect [2,3].
Source: Experimental Hematology - Category: Hematology Authors: Tags: Review Source Type: research