Cell-type deconvolution of bulk-blood RNA-seq reveals biological insights into neuropsychiatric disorders

Methods aimed at deconvolving cell-type-specific estimates of bulk gene expression offer a cost-effective way to investigate cell-type-specific eQTLs. Our study suggests that such computational approaches to a large sample with blood-based bulk RNA-seq significantly increase the opportunity to interpret the underlying biology of brain-specific disease susceptibility.

Source: The American Journal of Human Genetics - February 1, 2024 Category: Genetics & Stem Cells Authors: Toni Boltz, Tommer Schwarz, Merel Bot, Kangcheng Hou, Christa Caggiano, Sandra Lapinska, Chenda Duan, Marco P. Boks, Rene S. Kahn, Noah Zaitlen, Bogdan Pasaniuc, Roel Ophoff Tags: Article Source Type: research