PET-CT-guided versus CT-guided biopsy in suspected malignant pleural thickening: a randomised trial

Extract Pleural malignancy represents either metastases from another primary site (often lung, breast or ovarian) or primary pleural malignancy from pleural mesothelioma [1]. Pleural malignancy, especially pleural mesothelioma, can be challenging to diagnose due to the patchy distribution of heterogenous tumour across the pleural surface [2]. Pleural biopsy via image guidance or thoracoscopy has a false negative rate of 10–25% [3, 4]. For those with a non-diagnostic first pleural biopsy, but ongoing clinical or radiological suspicion of malignancy, the optimal approach is unclear.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Original Articles: Imaging and pleural disease Source Type: research