Minor Introns Impact on Hematopoietic Malignancies

In the central dogma of molecular biology, transcription from DNA is a pivotal process wherein messenger RNA (mRNA) serves as the key intermediate between the genetic code stored in DNA and the functional proteins. This initial step involves transcribing genetic information into precursor mRNA (pre-mRNA), which subsequently undergoes essential RNA processing steps, including 5 ′ capping, 3′ polyadenylation (poly(A) tail), pre-mRNA splicing and mRNA transport to the cytosol. The quantity and quality control of pre-mRNA is intricately regulated by various factors, including transcriptional regulators, RNA binding proteins (RBPs), and chromatin architecture, as well as p ost-transcriptional regulation, such as base editing and chemical modifications (e.g., N6-methyladenosine, m6A) [1–4].
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research