Navigating the Landscape of Liver Cancer Management: Study Designs in Clinical Trials and Clinical Practices

Randomized controlled trials (RCTs) represent the gold standard for evidence generation across all areas of medicine and especially in the oncology field, as they allow unbiased estimates of treatment effect without confounders. Observational studies have many problems that could reduce their internal and external validity. However, large prospective (well-conducted) observational real-world studies (RWS) can detect the occurrence of rare adverse events or monitoring for long-term adverse events.

Source: Journal of Hepatology - January 31, 2024 Category: Gastroenterology Authors: Giuseppe Cabibbo, Ciro Celsa, Lorenza Rimassa, Ferran Torres, Jordi Rimola, Roman Kloeckner, Jordi Bruix, Calogero Camm à, Maria Reig Tags: Review Source Type: research