CPT1B maintains redox homeostasis and inhibits ferroptosis to induce gemcitabine resistance via the KEAP1/NRF2 axis in pancreatic cancer

Although we have made progress in treatment and have increased the 5-year survival by ≤30% in pancreatic cancer, chemotherapy resistance remains a major obstacle. However, whether reprogrammed lipid metabolism contributes to chemoresistance still needs to be further studied.

Source: Surgery - January 31, 2024 Category: Surgery Authors: Abudureyimu Tuerhong, Jin Xu, Wei Wang, Si Shi, Qingcai Meng, Jie Hua, Jiang Liu, Bo Zhang, Xianjun Yu, Chen Liang Source Type: research