Characterization of Blood –Brain Barrier Opening Induced by Transcranial Histotripsy in Murine Brains

Transcranial histotripsy has shown promise as a non-invasive neurosurgical tool, as it has the ability to treat a wide range of locations in the brain without overheating the skull. One important effect of histotripsy in the brain is the blood –brain barrier (BBB) opening (BBBO) at the ablation site, but there is a knowledge gap concerning the extent of histotripsy-induced BBBO. Here we describe induction of BBBO by transcranial histotripsy and use of magnetic resonance imaging (MRI) and histology to quantify changes in BBBO at the peri phery of the histotripsy ablation zone over time in the healthy mouse brain.

Source: Ultrasound in Medicine and Biology - January 31, 2024 Category: Radiology Authors: Sarah Duclos, Sang Won Choi, Anuska V. Andjelkovic, Neeraj Chaudhary, Sandra Camelo-Piragua, Aditya Pandey, Zhen Xu Tags: Original Contribution Source Type: research