Metabolomic data presents challenges for epidemiological meta-analysis: a case study of childhood body mass index from the ECHO consortium

ConclusionsDespite including three cohorts with large sample sizes (N  >  100), we failed to identify significant metabolite associations after FDR correction. Our investigation demonstrates difficulties in applying epidemiological meta-analysis to clinical metabolomics, emphasizes challenges to reproducibility, and highlights the need for standardized best practices i n metabolomic epidemiology.
Source: Metabolomics - Category: Biology Source Type: research