A Genotype-Phenotype Model for Predicting Resistance Training Effects on Leg Press Performance
This study develops a comprehensive genotype-phenotype model for predicting the
effects of resistance training on leg press performance. A cohort of physically
inactive adults (N=193) underwent 12 weeks of resistance training, and
measurements of maximum isokinetic leg press peak force, muscle mass, and
thickness were taken before and after the intervention. Whole-genome genotyping
was performed, and genome-wide association analysis identified 85 novel SNPs
significantly associated with changes in leg press strength after training. A
prediction model was constructed using stepwise linear regression, incorporating
seven lead SNPs that explained 40.4% of the training effect variance.
The polygenic score showed a significant positive correlation with changes in
leg press strength. By integrating genomic markers and phenotypic indicators,
the comprehensive prediction model explained 75.4% of the variance in
the training effect. Additionally, five SNPs were found to potentially impact
muscle contraction, metabolism, growth, and development through their
association with REACTOME pathways. Individual responses to resistance training
varied, with changes in leg press strength ranging from −55.83%
to 151.20%. The study highlights the importance of genetic factors in
predicting training outcomes and provides insight...
Source: International Journal of Sports Medicine - Category: Sports Medicine Authors: Mei, Tao Li, Yanchun Li, Xiaoxia Yang, Xiaolin Li, Liang Yan, Xu He, Zi-hong Tags: Genetics & Molecular Biology Source Type: research
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