The effect of a smaller spacer in the PASCAL Ace on residual mitral valve orifice area

ConclusionIn FMR patients with non-complex anatomy, the larger spacer of the P10 maintains greater MVOA with similar MR reduction. Hence, the use of the PASCAL Ace device in patients with small MVOAs might correlate with a risk of both clinically relevant orifice reduction and even iatrogenic stenosis.Graphical AbstractSeventy-two patients treated  for functional mitral regurgitation (FMR) with the narrower PASCAL Ace featuring a smaller spacer (n = 40) or the broader P10 with a larger spacer (n = 32) were included in this study. Using 3D TEE and multiplanar reconstruction for direct planimetry, mitral valve orifice areas (MVOA) were measured before and after device implantation. Only patients with central device positioning were included. The dimensions of the PASCAL device platform are shown as well. Note the larger space and broader design of the P10 compared to the PASCAL Ace. The difference in MVOA reduction amounted to 10%, which translates into roughly 0.5 cm2 based on an average MV found in this study.
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research