Low-flow in aortic valve stenosis patients with reduced ejection fraction does not depend on left ventricular function

ConclusionIn patients with low-flow severe aortic stenosis, low transaortic gradient and cardiac output are not primarily due to LV dysfunction or global changes in gene expression, but may be attributed to other additional cardiac pathologies like mitral regurgitation, atrial fibrillation or right ventricular dysfunction. These factors should also be considered during planning of aortic valve replacement.Graphical AbstractComparison of patients with high-gradient (HG) and low-gradient (LG) aortic stenosis (AS) and reduced ejection fraction. Comprehensive analyses including clinical data, gene expression analyses, cardiovascular magnetic resonance (CMR) imaging as well as echocardiography were performed. AF:  Atrial fibrillation, MR: mitral regurgitation, RVEF: right ventricular ejection fraction, ECV%: extracellular volume.
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research