Plasma Matrix Metalloproteinase Concentrations and Risk of Interstitial Lung Disease in a Prospective Rheumatoid Arthritis Cohort

ConclusionMMP-7 and MMP-9 were strongly associated with both prevalent and incident ILD in this large, multicenter RA cohort after adjustment for other RA-ILD risk factors. These population-level findings further support a potential pathogenic role for MMPs in RA-ILD and suggest that their measurement could facilitate RA-ILD risk stratification.

Source: Arthritis and Rheumatology - January 25, 2024 Category: Rheumatology Authors: Brent A. Luedders, Austin M. Wheeler, Dana P. Ascherman, Joshua F. Baker, Michael J. Duryee, Yangyuna Yang, Punyasha Roul, Katherine D. Wysham, Paul Monach, Andreas Reimold, Gail S. Kerr, Gary Kunkel, Grant W. Cannon, Jill A. Poole, Geoffrey Tags: Full Length Source Type: research