Race, Genotype, and Prognosis in Black Patients with Transthyretin Cardiac Amyloidosis

Previous studies suggest worse outcomes in patients with variant transthyretin cardiac amyloidosis due to V122I (ATTRv-CA) compared to patients with wild-type disease (ATTRwt-CA). Given V122I is almost exclusively found in Black patients, it is unclear if this is attributable to the biology of genotype or racial differences. Patients with transthyretin cardiac amyloidosis (ATTR-CA) diagnosed between January 2001 and August 2021 were characterized into 3 categories: (1) White with ATTRwt-CA (White- WT); (2) Black with V122I ATTRv-CA (Black-V122I), and (3) Black with ATTRwt-CA (Black-WT).
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research