Cell fate decision in erythropoiesis: insights from multi-omics studies.

Erythropoiesis is an important cellular differentiation process that leads to the formation of red blood cells from hematopoietic stem cells (HSCs) [1,2]. Owing to sophisticated mouse models [3] and human ex vivo differentiation systems that recapitulate all steps of differentiation [4], erythropoiesis has been comprehensibly analyzed, which makes it an ideal model system to address outstanding questions in biology. For example, enhancers were first characterized through extensive analyses of transcription at the ß-globin locus during erythroid differentiation [5].

Source: Experimental Hematology - January 20, 2024 Category: Hematology Authors: Steven Tur, Carmen G. Palii, Marjorie Brand Source Type: research