Key inflammatory markers in bronchoalveolar lavage predict bronchiectasis progression in young children with CF

Progression of structural lung disease over time is an important cause of mortality in people with cystic fibrosis (CF). A large proportion of children with CF have already developed bronchiectasis by the age of 5 years [1]. Inflammation plays an important role in the pathogenesis of lung disease in early stages of CF. The lungs of children with CF contain large numbers of neutrophils and increased concentrations of pro-inflammatory cytokines and neutrophil effector proteins [2]. Prior longitudinal studies of young children with CF have shown that specific inflammatory markers correlate with structural lung disease and can predict an increased risk for development of bronchiectasis [3 –5].

Source: Journal of Cystic Fibrosis - January 20, 2024 Category: Respiratory Medicine Authors: Hamed Horati, Camilla Margaroli, Joshua D. Chandler, Matthew B. Kilgore, Badies Manai, Eleni-Rosalina Andrinopoulou, Limin Peng, Lokesh Guglani, Harm A.M.W. Tiddens, Daan Caudri, Bob J. Scholte, Rabindra Tirouvanziam, HettieM. Janssens Tags: Original Article Source Type: research