Heme ‐induced corpus cavernosum relaxation and its implications for priapism in sickle cell disease: a mechanistic insight

Discussion and conclusionThe HO –CO–sGC–cGMP pathway appears to play a crucial role in promoting CC relaxation. Our study provides novel insight into the role of group heme in CC relaxation and its potential contribution to priapism in SCD. Heme may serve as a pharmacological target for new therapies to prevent priapism.

Source: Andrology - January 17, 2024 Category: Urology & Nephrology Authors: Dalila Andrade Pereira, Danillo Andrade Pereira, Tammyris Helena Rebecchi Silveira, Fabiano Beraldi Calmasini, Arthur L. Burnett, Fernando Ferreira Costa, F ábio Henrique Silva Tags: ORIGINAL ARTICLE Source Type: research