Efficacy of Immune Checkpoint Inhibitors for Metastatic Colorectal Cancer with Microsatellite Instability in Second or Latter Line Using Synthetic Control Arms: A non-Randomised Evaluation

Immune checkpoint inhibitors (ICIs) appeared active in single-arm trials for patients with chemoresistant metastatic colorectal cancer (mCRC) harboring microsatellite instability (MSI). Given the paucity of randomised controlled trials (RCTs) in this setting, we evaluated the effect size of ICIs using intra-patients comparison and ARCAD database as historical controls.

Source: European Journal of Cancer - January 14, 2024 Category: Cancer & Oncology Authors: Romain Cohen, Morteza Raeisi, Benoist Chibaudel, Takayuki Yoshino, Qian Shi, John R. Zalcberg, Richard Adams, Chiara Cremolini, Axel Grothey, Robert J. Mayer, Eric Van Cutsem, Josep Tabernero, Hideaki Bando, Toshihiro Misumi, Michael J Overman, Thierry An Tags: Original Research Source Type: research