Fasudil mediates neuroprotection in ischemia/reperfusion by modulating the ROCK-PPAR α-NOX axis

CONCLUSIONS: In mice, the neuroprotective effect of Fasudil depends on the expression of PPARα induced by ROCK-PPARα-NOX axis-mediated reduction in ROS and associated oxidative damage.PMID:38055403 | PMC:PMC10691184 | DOI:10.1590/acb387023

Source: Acta Cirurgica Brasileira - December 6, 2023 Category: Surgery Authors: Xitong Yang Guangming Wang Source Type: research