Transient anticonvulsant effects of time-restricted feeding in the 6-Hz mouse model

CONCLUSIONS: Both continuous and 2:5 TRF regimens transiently increased seizure thresholds in the 6-Hz model at around 2 weeks, which coincided with stability of blood glucose levels during the fed and fasted periods. Our findings suggest that the lack of prolonged anticonvulsant effects in the acute electrical seizure models employed may be attributed to only modest metabolic and antioxidant adaptations found in the brain and liver. Our findings underscore the potential therapeutic value of TRF in managing seizure-related conditions.PMID:38184948 | DOI:10.1016/j.yebeh.2023.109618

Source: Epilepsy and Behaviour - January 7, 2024 Category: Neurology Authors: Oliver J Armstrong Elliott S Neal Diana Vidovic Weizhi Xu Karin Borges Source Type: research