Molecular and Pathologic Characterization of YAP1-Expressing Small Cell Lung Cancer Cell Lines Leads to Reclassification as SMARCA4-Deficient Malignancies

CONCLUSIONS: SMARCA4-mutant SCLC-Y cell lines exhibit characteristics consistent with SMARCA4-deficient malignancies rather than SCLC. Our findings suggest that, unlike ASCL1, NEUROD1, and POU2F3, YAP1 is not a subtype defining transcription factor in SCLC.PMID:38180245 | DOI:10.1158/1078-0432.CCR-23-2360

Source: Clinical Cancer Research - January 5, 2024 Category: Cancer & Oncology Authors: Jin Ng Ling Cai Luc Girard Owen W J Prall Neeha Rajan Christine Khoo Ahida Batrouney David J Byrne Danielle K Boyd Ariena J Kersbergen Michael Christie John D Minna Marian L Burr Kate D Sutherland Source Type: research