Synthesis of substituted 2H-Chromenes via Pd-catalyzed C-H activation and thermal cyclization

Carbohydr Res. 2023 Dec 23;536:109018. doi: 10.1016/j.carres.2023.109018. Online ahead of print.ABSTRACTA proficient approach has been developed for the synthesis of substituted 2H-chromenes from C1-substituted glucal. The key step of our synthetic methodology was C-H activation in propylene carbonate solvent followed by 6π-electrocyclization aromatization in ethylene glycol as greener substitutes to toxic aprotic solvents, to obtain 2H-chromenes in a stepwise manner. The application of the developed methodology was further explored with the synthesis of a small library of substituted 2H-chromenes in good yields.PMID:38185030 | DOI:10.1016/j.carres.2023.109018

Source: Carbohydrate Research - January 7, 2024 Category: Genetics & Stem Cells Authors: Vipin K Maikhuri Vineet Verma Divya Mathur Ashok K Prasad Vinod Khatri Source Type: research