Sleep and circadian rhythm disruptions in behavioral variant frontotemporal dementia

DISCUSSION: Patients with bvFTD showed longer sleep duration, lower sleep quality, and rest-activity rhythm alterations. Actigraphy could serve as a cost-effective and accessible tool for ecologically monitoring changes in sleep duration in bvFTD patients.HIGHLIGHTS: We assessed sleep and circadian rhythms in behavioral variant frontotemporal dementia (bvFTD) using actigraphy. Patients with bvFTD show increased sleep duration and reduced sleep quality. Patients with bvFTD show rest-activity alterations in the morning and early afternoon. Sleep duration is associated with reduced cortical thickness in frontal regions. These alterations may represent an early sign of neurodegeneration.PMID:38183333 | DOI:10.1002/alz.13570

Source: The Journal of Alzheimers Association - January 6, 2024 Category: Psychiatry Authors: Marco Filardi Valentina Gnoni Ludovica Tamburrino Salvatore Nigro Daniele Urso Davide Vilella Benedetta Tafuri Alessia Giugno Roberto De Blasi Stefano Zoccolella Giancarlo Logroscino Source Type: research