Clotrimazole reverses macrophage M2 polarization by disrupting the PI3K/AKT/mTOR pathway

In this study, we show that CTZ downregulated M2-activation markers in macrophages polarized to the M2 profile. This effect occurred without interfering with the expression of M1-polarized markers or pro-inflammatory cytokines and signaling. Moreover, CTZ suppressed NFkB pathway intermediates and disrupted PI3K/AKT/mTOR signaling. We concluded that CTZ reverses macrophage M2 polarization by disrupting the PI3K/AKT/mTOR pathway, which results in the suppression of NFkB induction of M2 polarization. In addition, we find that CTZ represents a promising therapeutic tool as an antitumor agent.PMID:38176247 | DOI:10.1016/j.bbrc.2023.149455

Source: Biochemical and Biophysical Research communications - January 4, 2024 Category: Biochemistry Authors: Jos é Xavier do Nascimento Júnior Mauro Sola-Penna Patricia Zancan Source Type: research