The effects of long-term dienogest therapy on in vitro fertilization outcomes in women with endometriosis: a systematic review and meta-analysis

CONCLUSIONS: Out of 191 publications, five studies with 723 participants were included. Uncertainty persists on whether prolonged dienogest affects live birth (RR 1.42, 95% CI 0.29 to 6.84; 3 studies, n = 289; I2 86%) and clinical pregnancy rates (RR 1.33, 95% CI 0.31 to 5.65; 3 studies, n = 289; I2 86%) compared to conventional IVF. Moreover, uncertainty remains regarding intervention impact on live birth (RR 1.46, 95% CI 0.63 to 3.37; 1 study, n = 34) and clinical pregnancy rates (RR 1.32, 95% CI 0.78 to 2.23; 3 studies, n = 288; I2 0%) versus long-term GnRH agonist therapy before IVF. Given limited data and very low evidence quality, doubts arise about benefits of long-term dienogest pre-treatment before conventional IVF in endometriosis patients.PMID:38176680 | DOI:10.1016/j.jogc.2023.102339
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Authors: Source Type: research