The Effect of Sodium –Glucose Cotransporter Inhibitors on Renal Function as Adjunctive to Insulin in Adults with Type 1 Diabetes: An Updated Multilevel Meta-analysis of Randomized Controlled Trials

ConclusionOur findings suggest that adjunctive therapy with SGLT inhibitors results in a significant reduction in albuminuria, while their use is associated with a neutral effect on creatinine clearance, as a measure of renal function. Future renal outcome trials are needed to assess SGLT inhibitors ’ role in the pharmacological armamentarium against diabetic nephropathy in T1D.
Source: Diabetes Therapy - Category: Endocrinology Source Type: research