A Differential Protein Study on Bronchoalveolar Lavage Fluid at Different Stages of Silicosis

CONCLUSION: The main biological changes in the early stage of silicosis are glycolysis or gluconeogenesis, autoimmunity, carbon metabolism, phagocytosis, etc., and microfibril-associated glycoprotein 4 may be involved in the early stage of silicosis. The main biological changes in the late stage of silicosis are autoimmunity, intercellular adhesion, etc. Calcium hippocampus binding protein may participate in the biological changes in the late stage of silicosis. It provides a new idea to understand the pathogenesis of silicosis and also raises new questions for follow-up research.PMID:38173059 | DOI:10.2174/0113862073260760231023055036

Source: Combinatorial Chemistry and High Throughput Screening - January 4, 2024 Category: Chemistry Authors: Xiaoxuan Zhang Ke Han Linhui Kan Zheng Zhang Yihong Gong Shuyu Xiao Yuping Bai Nan Liu Chunyan Meng Huisheng Qi Fuhai Shen Source Type: research