Toll-like receptor expression and functional behavior in platelets from patients with systemic lupus erythematosus

CONCLUSION: Our study demonstrates normal platelet TLR expression and function together with increased circulating platelet-monocyte aggregates. In addition, a direct correlation was observed between plasma HMGB1 levels and platelet vWf release following TLR2 stimulation. This platelet behavior in a group of patients undergoing HCQ treatment suggests that platelets could play a role in the inflammatory state of SLE.PMID:38159527 | DOI:10.1016/j.imbio.2023.152782

Source: Immunobiology - December 30, 2023 Category: Allergy & Immunology Authors: Mar ía C Baroni Pietto Ana C Glembotsky Paola R Lev Cecilia R Mar ín Oyarzún Geraldine De Luca Graciela Gomez Mar ía V Collado Nancy Char ó Adela S Cellucci Paula G Heller Nora P Goette Rosana F Marta Source Type: research