Silencing of aryl hydrocarbon receptor repressor restrains Th17  cell immunity in autoimmune hepatitis

In conclusion, blockade of AHRR in AIH restores Th17-cell response to AHR, and limits Th17-cell differentiation through generation of uridine. In vivo, silencing of AHRR attenuates liver damage in NOD/scid/gamma mice. Blockade of AHRR might therefore represent a novel therapeutic strategy to modulate effector Th17-cell immunity and restore homeostasis in AIH.PMID:38142533 | DOI:10.1016/j.jaut.2023.103162

Source: Journal of Autoimmunity - December 24, 2023 Category: Allergy & Immunology Authors: Li Gao Wei Zhang Lina Zhang Barbora Gromova Guanqing Chen Eva Csizmadia Cortney Cagle Silvia Nastasio Yun Ma Alan Bonder Vilas Patwardhan Simon C Robson Sizun Jiang Maria Serena Longhi Source Type: research